Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bound to an aromatic aglycon tail. Here, we develop s...
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Full title
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters
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TN_cdi_doaj_primary_oai_doaj_org_article_028c1db90c9e4f9fab9c0de09fee91eb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_028c1db90c9e4f9fab9c0de09fee91eb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07700-1
