Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy effic...
Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME
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England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Immune checkpoint inhibitors (ICI) have dramatically improved the life expectancy of patients with metastatic melanoma. However, about half of the patient population still present resistance to these treatments. We have previously shown Notch1 contributes to a non-inflamed TME in melanoma that reduces the response to ICI. Here, we addressed the the...
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Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME
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TN_cdi_doaj_primary_oai_doaj_org_article_02f457d9d27b4896be22ab657b8b7584
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_02f457d9d27b4896be22ab657b8b7584
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-024-03214-5
