Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
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Author / Creator
Chen, Junyi , Ni, Hanzhi , Meng, Zhao , Wang, Jing , Huang, Xiayang , Dong, Yansheng , Sun, Chao , Zhang, Yadan , Cui, Lei , Li, Jian , Jia, Xueshun , Meng, Qingbin and Li, Chunju
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Polyamines are essential for the growth of eukaryotic cells and can be dysregulated in tumors. Here we describe a strategy to deplete polyamines through host–guest encapsulation using a peptide-pillar[5]arene conjugate (P1P5A, P1 = RGDSK(N
3
)EEEE) as a supramolecular trap. The RGD in the peptide sequence allows the molecule to bind to integr...
Alternative Titles
Full title
Supramolecular trap for catching polyamines in cells as an anti-tumor strategy
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_036605c0fa524d228d5ca0375dc359af
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_036605c0fa524d228d5ca0375dc359af
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11553-7
