Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis...
Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria
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Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Background
Optimal anti-bacterial activity of meropenem requires maintenance of its plasma concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at least 40% of the dosing interval (fT > MIC > 40). We aimed to determine whether a 3-h extended infusion (EI) of meropenem achieves fT > MIC > 40 on the first and thi...
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Full title
Clinical pharmacokinetics of 3-h extended infusion of meropenem in adult patients with severe sepsis and septic shock: implications for empirical therapy against Gram-negative bacteria
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TN_cdi_doaj_primary_oai_doaj_org_article_036d498f144040938cce554087d56eb5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_036d498f144040938cce554087d56eb5
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ISSN
2110-5820
E-ISSN
2110-5820
DOI
10.1186/s13613-019-0622-8
