Interleukin 4-induced neuroprotection and regulation of microglia activation as a therapeutic approa...
Interleukin 4-induced neuroprotection and regulation of microglia activation as a therapeutic approach in the MPTP model of Parkinson's disease
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India: Medknow Publications and Media Pvt. Ltd
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English
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India: Medknow Publications and Media Pvt. Ltd
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[...]neutralization of endogenous microglia-derived IL-4 in these cultures augmented the MPP+-induced loss of mDA neurons. The protective effect of IL-4 was at least in part mediated by increased expression and release of insulin-like growth factor 1 (IGF-1), a potent neurotrophic factor for mDA neurons. [...]the systemic injections of MPTP and the...
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Full title
Interleukin 4-induced neuroprotection and regulation of microglia activation as a therapeutic approach in the MPTP model of Parkinson's disease
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TN_cdi_doaj_primary_oai_doaj_org_article_0382a03bfd8b4a82945bb930c0f242b2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0382a03bfd8b4a82945bb930c0f242b2
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ISSN
1673-5374
E-ISSN
1876-7958
DOI
10.4103/1673-5374.215250
