Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
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Author / Creator
Mihola, Ondrej , Landa, Vladimir , Pratto, Florencia , Brick, Kevin , Kobets, Tatyana , Kusari, Fitore , Gasic, Srdjan , Smagulova, Fatima , Grey, Corinne , Flachs, Petr , Gergelits, Vaclav , Tresnak, Karel , Silhavy, Jan , Mlejnek, Petr , Camerini-Otero, R Daniel , Pravenec, Michal , Petukhova, Galina V and Trachtulec, Zdenek
Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Scope and Contents
Contents
Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catalyze H3K4me3 and H3K36me3 and determine hotspot positions, whereas other vertebrates lacking PRDM9 recombine in regions w...
Alternative Titles
Full title
Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_03a0d82fd99840bf996152ad7bf19c03
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_03a0d82fd99840bf996152ad7bf19c03
Other Identifiers
ISSN
1741-7007
E-ISSN
1741-7007
DOI
10.1186/s12915-021-01017-0
