Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 b...
Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria
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Author / Creator
Hirata, Yusuke , Yamada, Yuto , Taguchi, Soma , Kojima, Ryota , Masumoto, Haruka , Kimura, Shinnosuke , Niijima, Takuya , Toyama, Takashi , Kise, Ryoji , Sato, Emiko , Uchida, Yasunori , Ito, Junya , Nakagawa, Kiyotaka , Taguchi, Tomohiko , Inoue, Asuka , Saito, Yoshiro , Noguchi, Takuya and Matsuzawa, Atsushi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Conjugated fatty acids (CFAs) have been known for their anti-tumor activity. However, the mechanism of action remains unclear. Here, we identify CFAs as inducers of glutathione peroxidase 4 (GPX4) degradation through chaperone-mediated autophagy (CMA). CFAs, such as (10
E
,12
Z
)-octadecadienoic acid and α-eleostearic acid (ESA), induce...
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Full title
Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria
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TN_cdi_doaj_primary_oai_doaj_org_article_03c5af266e5e42b0a6a6c297d28bbde4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_03c5af266e5e42b0a6a6c297d28bbde4
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-07237-w
