Assessment of polygenic architecture and risk prediction based on common variants across fourteen ca...
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
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Author / Creator
Zhang, Yan Dora , Hurson, Amber N. , Zhang, Haoyu , Choudhury, Parichoy Pal , Easton, Douglas F. , Milne, Roger L. , Simard, Jacques , Hall, Per , Michailidou, Kyriaki , Dennis, Joe , Schmidt, Marjanka K. , Chang-Claude, Jenny , Gharahkhani, Puya , Whiteman, David , Campbell, Peter T. , Hoffmeister, Michael , Jenkins, Mark , Peters, Ulrike , Hsu, Li , Gruber, Stephen B. , Casey, Graham , Schmit, Stephanie L. , O’Mara, Tracy A. , Spurdle, Amanda B. , Thompson, Deborah J. , Tomlinson, Ian , De Vivo, Immaculata , Landi, Maria Teresa , Law, Matthew H. , Iles, Mark M. , Demenais, Florence , Kumar, Rajiv , MacGregor, Stuart , Bishop, D. Timothy , Ward, Sarah V. , Bondy, Melissa L. , Houlston, Richard , Wiencke, John K. , Melin, Beatrice , Barnholtz-Sloan, Jill , Kinnersley, Ben , Wrensch, Margaret R. , Amos, Christopher I. , Hung, Rayjean J. , Brennan, Paul , McKay, James , Caporaso, Neil E. , Berndt, Sonja I. , Birmann, Brenda M. , Camp, Nicola J. , Kraft, Peter , Rothman, Nathaniel , Slager, Susan L. , Berchuck, Andrew , Pharoah, Paul D. P. , Sellers, Thomas A. , Gayther, Simon A. , Pearce, Celeste L. , Goode, Ellen L. , Schildkraut, Joellen M. , Moysich, Kirsten B. , Amundadottir, Laufey T. , Jacobs, Eric J. , Klein, Alison P. , Petersen, Gloria M. , Risch, Harvey A. , Stolzenberg-Solomon, Rachel Z. , Wolpin, Brian M. , Li, Donghui , Eeles, Rosalind A. , Haiman, Christopher A. , Kote-Jarai, Zsofia , Schumacher, Fredrick R. , Al Olama, Ali Amin , Purdue, Mark P. , Scelo, Ghislaine , Dalgaard, Marlene D. , Greene, Mark H. , Grotmol, Tom , Kanetsky, Peter A. , McGlynn, Katherine A. , Nathanson, Katherine L. , Turnbull, Clare , Wiklund, Fredrik , Chanock, Stephen J. , Chatterjee, Nilanjan , Garcia-Closas, Montserrat , Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON) , Endometrial Cancer Association Consortium (ECAC) , International Lung Cancer Consortium (ILCCO) , Pancreatic Cancer Case-Control Consortium (PanC4) , International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph) , Breast Cancer Association Consortium (BCAC) , Ovarian Cancer Association Consortium (OCAC) , Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) , Testicular Cancer Consortium (TECAC) , Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT) , Glioma International Case-Control Study (GICC) , Oral Cancer GWAS , Renal Cancer GWAS , Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium , Pancreatic Cancer Cohort Consortium (PanScan) , Colon Cancer Family Registry (CCFR) , Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Melanoma Genetics Consortium (GenoMEL)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and under...
Alternative Titles
Full title
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
Authors, Artists and Contributors
Author / Creator
Hurson, Amber N.
Zhang, Haoyu
Choudhury, Parichoy Pal
Easton, Douglas F.
Milne, Roger L.
Simard, Jacques
Hall, Per
Michailidou, Kyriaki
Dennis, Joe
Schmidt, Marjanka K.
Chang-Claude, Jenny
Gharahkhani, Puya
Whiteman, David
Campbell, Peter T.
Hoffmeister, Michael
Jenkins, Mark
Peters, Ulrike
Hsu, Li
Gruber, Stephen B.
Casey, Graham
Schmit, Stephanie L.
O’Mara, Tracy A.
Spurdle, Amanda B.
Thompson, Deborah J.
Tomlinson, Ian
De Vivo, Immaculata
Landi, Maria Teresa
Law, Matthew H.
Iles, Mark M.
Demenais, Florence
Kumar, Rajiv
MacGregor, Stuart
Bishop, D. Timothy
Ward, Sarah V.
Bondy, Melissa L.
Houlston, Richard
Wiencke, John K.
Melin, Beatrice
Barnholtz-Sloan, Jill
Kinnersley, Ben
Wrensch, Margaret R.
Amos, Christopher I.
Hung, Rayjean J.
Brennan, Paul
McKay, James
Caporaso, Neil E.
Berndt, Sonja I.
Birmann, Brenda M.
Camp, Nicola J.
Kraft, Peter
Rothman, Nathaniel
Slager, Susan L.
Berchuck, Andrew
Pharoah, Paul D. P.
Sellers, Thomas A.
Gayther, Simon A.
Pearce, Celeste L.
Goode, Ellen L.
Schildkraut, Joellen M.
Moysich, Kirsten B.
Amundadottir, Laufey T.
Jacobs, Eric J.
Klein, Alison P.
Petersen, Gloria M.
Risch, Harvey A.
Stolzenberg-Solomon, Rachel Z.
Wolpin, Brian M.
Li, Donghui
Eeles, Rosalind A.
Haiman, Christopher A.
Kote-Jarai, Zsofia
Schumacher, Fredrick R.
Al Olama, Ali Amin
Purdue, Mark P.
Scelo, Ghislaine
Dalgaard, Marlene D.
Greene, Mark H.
Grotmol, Tom
Kanetsky, Peter A.
McGlynn, Katherine A.
Nathanson, Katherine L.
Turnbull, Clare
Wiklund, Fredrik
Chanock, Stephen J.
Chatterjee, Nilanjan
Garcia-Closas, Montserrat
Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
Endometrial Cancer Association Consortium (ECAC)
International Lung Cancer Consortium (ILCCO)
Pancreatic Cancer Case-Control Consortium (PanC4)
International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph)
Breast Cancer Association Consortium (BCAC)
Ovarian Cancer Association Consortium (OCAC)
Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL)
Testicular Cancer Consortium (TECAC)
Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT)
Glioma International Case-Control Study (GICC)
Oral Cancer GWAS
Renal Cancer GWAS
Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium
Pancreatic Cancer Cohort Consortium (PanScan)
Colon Cancer Family Registry (CCFR)
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
Melanoma Genetics Consortium (GenoMEL)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_043bfd656ef148a0993f50953c04b25f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_043bfd656ef148a0993f50953c04b25f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16483-3
