In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfu...
In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes
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The Company of Biologists Ltd
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Language
English
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The Company of Biologists Ltd
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Interconnected mechanisms of ischemia and reperfusion (IR) has increased the interest in IR in vitro experiments using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). We developed a whole-cell computational model of hiPSC-CMs including the electromechanics, a metabolite-sensitive sarcoplasmic reticulum Ca2+-ATPase (SERCA) an...
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Full title
In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes
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TN_cdi_doaj_primary_oai_doaj_org_article_044918ed8a244aec9b7eb30c33b31c78
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_044918ed8a244aec9b7eb30c33b31c78
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ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.050365
