DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
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Author / Creator
Wang, Yejinpeng , Ju, Lingao , Wang, Gang , Qian, Kaiyu , Jin, Wan , Li, Mingxing , Yu, Jingtian , Shi, Yiliang , Wang, Yongzhi , Zhang, Yi , Xiao, Yu and Wang, Xinghuan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
To date, most studies on the DNA polymerase, POLD1, have focused on the effect of POLD1 inactivation mutations in tumors. However, the implications of high POLD1 expression in tumorigenesis remains elusive. Here, we determine that POLD1 has a pro-carcinogenic role in bladder cancer (BLCA) and is associated to the malignancy and prognosis of BLCA. O...
Alternative Titles
Full title
DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0481f6182dcc4b7ea3c871bd734e6395
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0481f6182dcc4b7ea3c871bd734e6395
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-38160-x
