Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
About this item
Full title
Author / Creator
Baker, Ann-Marie , Huang, Weini , Wang, Xiao-Ming Mindy , Jansen, Marnix , Ma, Xiao-Jun , Kim, Jeffrey , Anderson, Courtney M. , Wu, Xingyong , Pan, Liuliu , Su, Nan , Luo, Yuling , Domingo, Enric , Heide, Timon , Sottoriva, Andrea , Lewis, Annabelle , Beggs, Andrew D. , Wright, Nicholas A. , Rodriguez-Justo, Manuel , Park, Emily , Tomlinson, Ian and Graham, Trevor A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and validating BaseScope—a novel mutation-specific RNA in...
Alternative Titles
Full title
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution
Authors, Artists and Contributors
Author / Creator
Huang, Weini
Wang, Xiao-Ming Mindy
Jansen, Marnix
Ma, Xiao-Jun
Kim, Jeffrey
Anderson, Courtney M.
Wu, Xingyong
Pan, Liuliu
Su, Nan
Luo, Yuling
Domingo, Enric
Heide, Timon
Sottoriva, Andrea
Lewis, Annabelle
Beggs, Andrew D.
Wright, Nicholas A.
Rodriguez-Justo, Manuel
Park, Emily
Tomlinson, Ian
Graham, Trevor A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_04a8b784261d4d7da0ef04bead32687f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_04a8b784261d4d7da0ef04bead32687f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02295-5
