NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
About this item
Full title
Author / Creator
Gleixner, Amanda M. , Verdone, Brandie Morris , Otte, Charlton G. , Anderson, Eric N. , Ramesh, Nandini , Shapiro, Olivia R. , Gale, Jenna R. , Mauna, Jocelyn C. , Mann, Jacob R. , Copley, Katie E. , Daley, Elizabeth L. , Ortega, Juan A. , Cicardi, Maria Elena , Kiskinis, Evangelos , Kofler, Julia , Pandey, Udai B. , Trotti, Davide and Donnelly, Christopher J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
A G4C2 hexanucleotide repeat expansion in the
C9orf72
gene is the most common genetic cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions observed in regions of neurodegeneration. The accumulation of repetitive RNAs and dipeptide repeat protein (DPR) are two proposed mechanisms of toxicity in C9-ALS/FTLD and linked to impai...
Alternative Titles
Full title
NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility
Authors, Artists and Contributors
Author / Creator
Verdone, Brandie Morris
Otte, Charlton G.
Anderson, Eric N.
Ramesh, Nandini
Shapiro, Olivia R.
Gale, Jenna R.
Mauna, Jocelyn C.
Mann, Jacob R.
Copley, Katie E.
Daley, Elizabeth L.
Ortega, Juan A.
Cicardi, Maria Elena
Kiskinis, Evangelos
Kofler, Julia
Pandey, Udai B.
Trotti, Davide
Donnelly, Christopher J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_04c38fed278645e2a4a1f52a4ea229f4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_04c38fed278645e2a4a1f52a4ea229f4
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31098-6
