Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
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England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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Contents
Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca2+-dependent lipid scramblase, its regulation mechanism has remained elusive. Here, we have used cryo-electron microscopy and functional assays to address this question....
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Full title
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
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TN_cdi_doaj_primary_oai_doaj_org_article_04d9dc8eece3466fb805d02d7b6896f0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_04d9dc8eece3466fb805d02d7b6896f0
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.44364
