Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages fo...
Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages for refractory colorectal cancer treatment
About this item
Full title
Author / Creator
Wang, Jun , Deng, Shenghe , Cheng, Denglong , Gu, Junnan , Qin, Le , Mao, Fuwei , Xue, Yifan , Jiang, Zhenxin , Chen, Mian , Zou, Falong , Huang, Ning , Cao, Yinghao and Cai, Kailin
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Arginase is abundantly expressed in colorectal cancer and disrupts arginine metabolism, promoting the formation of an immunosuppressive tumor microenvironment. This significant factor contributes to the insensitivity of colorectal cancer to immunotherapy. Tumor-associated macrophages (TAMs) are major immune cells in this environment, and aberrant a...
Alternative Titles
Full title
Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages for refractory colorectal cancer treatment
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_052069f576204ee58689413a7140d3f9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_052069f576204ee58689413a7140d3f9
Other Identifiers
ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-024-05652-3
