Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metas...
Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
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Huang, Chongbiao , Li, Na , Li, Zengxun , Chang, Antao , Chen, Yanan , Zhao, Tiansuo , Li, Yang , Wang, Xiuchao , Zhang, Wei , Wang, Zhimin , Luo, Lin , Shi, Jingjing , Yang, Shengyu , Ren, He and Hao, Jihui
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting of an EBV-induced gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immune-suppressive cytokine mainly produced by regulatory T cells. However, the role of IL-35 in cancer metastasis and progression is not well understood. Here we demonstrate that IL-35 is overexpressed in...
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Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
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TN_cdi_doaj_primary_oai_doaj_org_article_05647a54a54d4a00b761a25ce2b1a8aa
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_05647a54a54d4a00b761a25ce2b1a8aa
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14035
