Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair c...
Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses
About this item
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Author / Creator
Michalski, Nicolas , Goutman, Juan D , Auclair, Sarah Marie , Boutet de Monvel, Jacques , Tertrais, Margot , Emptoz, Alice , Parrin, Alexandre , Nouaille, Sylvie , Guillon, Marc , Sachse, Martin , Ciric, Danica , Bahloul, Amel , Hardelin, Jean-Pierre , Sutton, Roger Bryan , Avan, Paul , Krishnakumar, Shyam S , Rothman, James E , Dulon, Didier , Safieddine, Saaid and Petit, Christine
Publisher
Cambridge: eLife Sciences Publications Ltd
Journal title
Language
English
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Publication information
Publisher
Cambridge: eLife Sciences Publications Ltd
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Scope and Contents
Contents
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C2-domain, Ca2+-binding transmembrane protein of synaptic vesicles. To decipher the role of otoferlin in the synaptic vesicle cycle, we produced knock-in mic...
Alternative Titles
Full title
Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses
Authors, Artists and Contributors
Author / Creator
Goutman, Juan D
Auclair, Sarah Marie
Boutet de Monvel, Jacques
Tertrais, Margot
Emptoz, Alice
Parrin, Alexandre
Nouaille, Sylvie
Guillon, Marc
Sachse, Martin
Ciric, Danica
Bahloul, Amel
Hardelin, Jean-Pierre
Sutton, Roger Bryan
Avan, Paul
Krishnakumar, Shyam S
Rothman, James E
Dulon, Didier
Safieddine, Saaid
Petit, Christine
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0573827227564a46bbf876f5400e53e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0573827227564a46bbf876f5400e53e1
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.31013
