EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
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Author / Creator
Zhang, Lin , Qu, Jingkun , Qi, Yutao , Duan, Yimin , Huang, Yu-Wen , Zhou, Zhifen , Li, Ping , Yao, Jun , Huang, Beibei , Zhang, Shuxing and Yu, Dihua
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
Bone metastases occur in 50–70% of patients with late-stage breast cancers and effective therapies are needed. The expression of enhancer of zeste homolog 2
(
EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn’t been well-explored. Here we report that EZH2 promotes osteolytic metastasis of breast cance...
Alternative Titles
Full title
EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_05aa232c6afd450daf8510c54d82f59b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_05aa232c6afd450daf8510c54d82f59b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30105-0
