Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients w...
Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors
About this item
Full title
Author / Creator
Conlon, Kevin , Watson, Dionysios C , Waldmann, Thomas A , Valentin, Antonio , Bergamaschi, Cristina , Felber, Barbara K , Peer, Cody J , Figg, William D , Potter, E Lake , Roederer, Mario , McNeel, Douglas G , Thompson, John A , Gupta, Sumati , Leidner, Rom , Wang-Gillam, Andrea , Parikh, Nehal S , Long, Debby , Kurtulus, Sema , Ho Lee, Lang , Chowdhury, Niladri Roy , Bender, Florent and Pavlakis, George N
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundNIZ985 is a recombinant heterodimer of physiologically active interleukin (IL-)15 and IL-15 receptor alpha. In preclinical models, NIZ985 promotes cytotoxic lymphocyte proliferation, killing function, and organ/tumor infiltration, with resultant anticancer effects. In this first-in-human study, we assessed the safety, pharmacokinetics, an...
Alternative Titles
Full title
Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors
Authors, Artists and Contributors
Author / Creator
Watson, Dionysios C
Waldmann, Thomas A
Valentin, Antonio
Bergamaschi, Cristina
Felber, Barbara K
Peer, Cody J
Figg, William D
Potter, E Lake
Roederer, Mario
McNeel, Douglas G
Thompson, John A
Gupta, Sumati
Leidner, Rom
Wang-Gillam, Andrea
Parikh, Nehal S
Long, Debby
Kurtulus, Sema
Ho Lee, Lang
Chowdhury, Niladri Roy
Bender, Florent
Pavlakis, George N
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_05cda4cb9225447c85e4cdf802228026
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_05cda4cb9225447c85e4cdf802228026
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-003388
