Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
About this item
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Author / Creator
Chan, Gary KL , Maisel, Samantha , Hwang, Yeonjoo C , Pascual, Bryan C , Wolber, Rebecca RB , Vu, Phuong , Patra, Krushna C , Bouhaddou, Mehdi , Kenerson, Heidi L , Lim, Huat C , Long, Donald , Yeung, Raymond S , Sethupathy, Praveen , Swaney, Danielle L , Krogan, Nevan J , Turnham, Rigney E , Riehle, Kimberly J , Scott, John D , Bardeesy, Nabeel and Gordan, John D
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: eLife Sciences Publications Ltd
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More information
Scope and Contents
Contents
Genetic alterations that activate protein kinase A (PKA) are found in many tumor types. Yet, their downstream oncogenic signaling mechanisms are poorly understood. We used global phosphoproteomics and kinase activity profiling to map conserved signaling outputs driven by a range of genetic changes that activate PKA in human cancer. Two signaling ne...
Alternative Titles
Full title
Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms
Authors, Artists and Contributors
Author / Creator
Maisel, Samantha
Hwang, Yeonjoo C
Pascual, Bryan C
Wolber, Rebecca RB
Vu, Phuong
Patra, Krushna C
Bouhaddou, Mehdi
Kenerson, Heidi L
Lim, Huat C
Long, Donald
Yeung, Raymond S
Sethupathy, Praveen
Swaney, Danielle L
Krogan, Nevan J
Turnham, Rigney E
Riehle, Kimberly J
Scott, John D
Bardeesy, Nabeel
Gordan, John D
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_05fc37cffa674796bf7877b4353fc32a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_05fc37cffa674796bf7877b4353fc32a
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.69521
