Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain in hard-to-transfect cells or in vivo. Here we engineer a chemically modified mRNA-encoded adenine...
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Full title
Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope
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TN_cdi_doaj_primary_oai_doaj_org_article_063c642bedca45fb8d0878850da6e48f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_063c642bedca45fb8d0878850da6e48f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15892-8
