Single-cell transcriptomics captures features of human midbrain development and dopamine neuron dive...
Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
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Author / Creator
Faculty of Medicine , Medicinska fakulteten , Human Neural Developmental Biology , Strategiska forskningsområden (SFO) , Department of Experimental Medical Science , StemTherapy: National Initiative on Stem Cells for Regenerative Therapy , Regenerative Neurophysiology , Utvecklings- och regenerativ neurobiologi , Human neural utvecklingsbiologi , Strategic research areas (SRA) , Lunds universitet , Profilområden och andra starka forskningsmiljöer , Lund University , MultiPark: Multidisciplinary research focused on Parkinson´s disease , Regenerativ neurofysiologi , Institutionen för experimentell medicinsk vetenskap , Profile areas and other strong research environments , Developmental and Regenerative Neurobiology , Fiorenzano, Alessandro , Sozzi, Edoardo , Birtele, Marcella , Kajtez, Janko , Giacomoni, Jessica , Nilsson, Fredrik , Bruzelius, Andreas , Sharma, Yogita , Zhang, Yu , Mattsson, Bengt , Emnéus, Jenny , Ottosson, Daniella Rylander , Storm, Petter and Parmar, Malin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Three-dimensional brain organoids have emerged as a valuable model system for studies of human brain development and pathology. Here we establish a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons. Using single cell RNA sequencing, we identify the presence of three molecul...
Alternative Titles
Full title
Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
Authors, Artists and Contributors
Author / Creator
Medicinska fakulteten
Human Neural Developmental Biology
Strategiska forskningsområden (SFO)
Department of Experimental Medical Science
StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Regenerative Neurophysiology
Utvecklings- och regenerativ neurobiologi
Human neural utvecklingsbiologi
Strategic research areas (SRA)
Lunds universitet
Profilområden och andra starka forskningsmiljöer
Lund University
MultiPark: Multidisciplinary research focused on Parkinson´s disease
Regenerativ neurofysiologi
Institutionen för experimentell medicinsk vetenskap
Profile areas and other strong research environments
Developmental and Regenerative Neurobiology
Fiorenzano, Alessandro
Sozzi, Edoardo
Birtele, Marcella
Kajtez, Janko
Giacomoni, Jessica
Nilsson, Fredrik
Bruzelius, Andreas
Sharma, Yogita
Zhang, Yu
Mattsson, Bengt
Emnéus, Jenny
Ottosson, Daniella Rylander
Storm, Petter
Parmar, Malin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0673168cfbbc48178fafc719524f253a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0673168cfbbc48178fafc719524f253a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27464-5
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