Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc r...
Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation
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Author / Creator
Kang, Donghyun , Lee, Jeeyeon , Yook, Geunho , Jeong, Sehan , Shin, Jungkwon , Kim, Mi-Sung , Kim, Yi-Jun , Jung, Hyeryeon , Ahn, Jinsung , Kim, Tae Woo , Chang, Moon Jong , Chang, Chong Bum , Kang, Seung-Baik , Yang, Won Ho , Lee, Yong-ho , Cho, Jin Won , Yi, Eugene C. , Kang, Chanhee and Kim, Jin-Hong
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
UDP-GlcNAc serves as a building block for glycosaminoglycan (GAG) chains in cartilage proteoglycans and simultaneously acts as a substrate for O-GlcNAcylation. Here, we show that transporters for UDP-GlcNAc to the endoplasmic reticulum (ER) and Golgi are significantly downregulated in osteoarthritic cartilage, leading to increased cytosolic UDP-Glc...
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Full title
Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation
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TN_cdi_doaj_primary_oai_doaj_org_article_06bf9c03dbf44a3d895097273164a3ca
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_06bf9c03dbf44a3d895097273164a3ca
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-55085-1
