An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel
An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. Such consideration is particularly relevant in human diseases associated to inherited mutations leading to structural instability, aggreg...
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Full title
An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel
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TN_cdi_doaj_primary_oai_doaj_org_article_06cb6d34b83948ddbd9c631e4790026c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_06cb6d34b83948ddbd9c631e4790026c
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ISSN
1741-7007
E-ISSN
1741-7007
DOI
10.1186/s12915-021-01040-1
