Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation
Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development, strongly suppresses GBM formation. Mechanistically, expression of several GBM-associated genes, inc...
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Full title
Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation
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TN_cdi_doaj_primary_oai_doaj_org_article_073bb96623004e5382578e901c23c945
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_073bb96623004e5382578e901c23c945
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.08711
