Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which can be toxic to cells and tissue. In a subset of frontotemporal lobar degeneration with tau pathology (FTLD-tau) cases, pathogenic mutations in the microtubule-associated protein tau (
MAPT...
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Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
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TN_cdi_doaj_primary_oai_doaj_org_article_07652dae38104a2e80527e122ae1d99c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_07652dae38104a2e80527e122ae1d99c
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ISSN
2158-3188
E-ISSN
2158-3188
DOI
10.1038/s41398-022-02274-5
