The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secre...
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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As a strategy to improve the therapeutic success of chimeric antigen receptor T cells (CART) directed against solid tumors, we here test the combinatorial use of CART and IMSA101, a newly developed stimulator of interferon genes (STING) agonist. In two syngeneic tumor models, improved overall survival is observed when mice are treated with intratum...
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The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
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TN_cdi_doaj_primary_oai_doaj_org_article_0776d7dc8ea14173bb63673e70265732
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0776d7dc8ea14173bb63673e70265732
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-47692-9
