926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy
926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy
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London: BMJ Publishing Group Ltd
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English
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London: BMJ Publishing Group Ltd
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BackgroundThe second messenger diacylglycerol plays a key role in T-cell receptor (TCR) downstream signaling and T-cell activation. Diacylglycerol kinase zeta (DGKζ) is a lipid kinase that regulates T-cell activation by phosphorylating diacylglycerol to produce phosphatidic acid, thereby acting as a ligand-independent, intracellular immune checkpoi...
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926 BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_07ab2b5c8fd7488eb234fe061e205932
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_07ab2b5c8fd7488eb234fe061e205932
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E-ISSN
2051-1426
DOI
10.1136/jitc-2023-SITC2023.0926
