Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
About this item
Full title
Author / Creator
Indrigo, Marzia , Morella, Ilaria , Orellana, Daniel , d'Isa, Raffaele , Papale, Alessandro , Parra, Riccardo , Gurgone, Antonia , Lecca, Daniela , Cavaccini, Anna , Tigaret, Cezar M , Cagnotto, Alfredo , Jones, Kimberley , Brooks, Simon , Ratto, Gian Michele , Allen, Nicholas D , Lelos, Mariah J , Middei, Silvia , Giustetto, Maurizio , Carta, Anna R , Tonini, Raffaella , Salmona, Mario , Hall, Jeremy , Thomas, Kerrie , Brambilla, Riccardo and Fasano, Stefania
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death
in vitro
and
in vivo
in the mouse brain, while attenuation of ERK signaling does the opposite. This neuroprotective effe...
Alternative Titles
Full title
Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
Authors, Artists and Contributors
Author / Creator
Morella, Ilaria
Orellana, Daniel
d'Isa, Raffaele
Papale, Alessandro
Parra, Riccardo
Gurgone, Antonia
Lecca, Daniela
Cavaccini, Anna
Tigaret, Cezar M
Cagnotto, Alfredo
Jones, Kimberley
Brooks, Simon
Ratto, Gian Michele
Allen, Nicholas D
Lelos, Mariah J
Middei, Silvia
Giustetto, Maurizio
Carta, Anna R
Tonini, Raffaella
Salmona, Mario
Hall, Jeremy
Thomas, Kerrie
Brambilla, Riccardo
Fasano, Stefania
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_07ec956f4df240a18ad3746f40460254
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_07ec956f4df240a18ad3746f40460254
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.202215984
