Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality an...
Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
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Full title
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Publisher
Beijing: Higher Education Press
Journal title
Language
English
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Publication information
Publisher
Beijing: Higher Education Press
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Scope and Contents
Contents
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogenei...
Alternative Titles
Full title
Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0823d816c57e4beba790b8fb829a159d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0823d816c57e4beba790b8fb829a159d
Other Identifiers
ISSN
1674-800X
E-ISSN
1674-8018
DOI
10.1007/s13238-017-0433-3
