Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vacc...
Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
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England: BMJ Publishing Group Ltd
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English
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England: BMJ Publishing Group Ltd
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BackgroundPD-L1 is one of the major immune checkpoints which limits the effectiveness of antitumor immunity. Blockade of PD-L1/PD-1 has been a major improvement in the treatment of certain cancers, however, the response rate to checkpoint blockade remains low suggesting a need for new therapies. Metformin has emerged as a potential new drug for the...
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Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_084f712d463c43b8b36ee6e0f2e59676
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_084f712d463c43b8b36ee6e0f2e59676
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-002614
