Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
About this item
Full title
Author / Creator
Colombo, Alessio , Dinkel, Lina , Müller, Stephan A. , Sebastian Monasor, Laura , Schifferer, Martina , Cantuti-Castelvetri, Ludovico , König, Jasmin , Vidatic, Lea , Bremova-Ertl, Tatiana , Lieberman, Andrew P. , Hecimovic, Silva , Simons, Mikael , Lichtenthaler, Stefan F. , Strupp, Michael , Schneider, Susanne A. and Tahirovic, Sabina
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in
NPC1
, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss on microglial function remain not fully characterized. We discovered pathological proteo...
Alternative Titles
Full title
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
Authors, Artists and Contributors
Author / Creator
Dinkel, Lina
Müller, Stephan A.
Sebastian Monasor, Laura
Schifferer, Martina
Cantuti-Castelvetri, Ludovico
König, Jasmin
Vidatic, Lea
Bremova-Ertl, Tatiana
Lieberman, Andrew P.
Hecimovic, Silva
Simons, Mikael
Lichtenthaler, Stefan F.
Strupp, Michael
Schneider, Susanne A.
Tahirovic, Sabina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_086477f8dbac4c818ed45236ab495029
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_086477f8dbac4c818ed45236ab495029
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21428-5
