MYCN amplification and ATRX mutations are incompatible in neuroblastoma
MYCN amplification and ATRX mutations are incompatible in neuroblastoma
About this item
Full title
Author / Creator
Zeineldin, Maged , Federico, Sara , Chen, Xiang , Fan, Yiping , Xu, Beisi , Stewart, Elizabeth , Zhou, Xin , Jeon, Jongrye , Griffiths, Lyra , Nguyen, Rosa , Norrie, Jackie , Easton, John , Mulder, Heather , Yergeau, Donald , Liu, Yanling , Wu, Jianrong , Van Ryn, Collin , Naranjo, Arlene , Hogarty, Michael D. , Kamiński, Marcin M. , Valentine, Marc , Pruett-Miller, Shondra M. , Pappo, Alberto , Zhang, Jinghui , Clay, Michael R. , Bahrami, Armita , Vogel, Peter , Lee, Seungjae , Shelat, Anang , Sarthy, Jay F. , Meers, Michael P. , George, Rani E. , Mardis, Elaine R. , Wilson, Richard K. , Henikoff, Steven , Downing, James R. and Dyer, Michael A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the
MYCN
oncogene and inactivation of the
ATRX
tumor-suppressor gene correlate with high-risk disease and poor prognosis. Here we show that
ATRX
mutations and
Alternative Titles
Full title
MYCN amplification and ATRX mutations are incompatible in neuroblastoma
Authors, Artists and Contributors
Author / Creator
Federico, Sara
Chen, Xiang
Fan, Yiping
Xu, Beisi
Stewart, Elizabeth
Zhou, Xin
Jeon, Jongrye
Griffiths, Lyra
Nguyen, Rosa
Norrie, Jackie
Easton, John
Mulder, Heather
Yergeau, Donald
Liu, Yanling
Wu, Jianrong
Van Ryn, Collin
Naranjo, Arlene
Hogarty, Michael D.
Kamiński, Marcin M.
Valentine, Marc
Pruett-Miller, Shondra M.
Pappo, Alberto
Zhang, Jinghui
Clay, Michael R.
Bahrami, Armita
Vogel, Peter
Lee, Seungjae
Shelat, Anang
Sarthy, Jay F.
Meers, Michael P.
George, Rani E.
Mardis, Elaine R.
Wilson, Richard K.
Henikoff, Steven
Downing, James R.
Dyer, Michael A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_08a87c1bf95d4f798e9e0d5a7daabd61
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_08a87c1bf95d4f798e9e0d5a7daabd61
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-14682-6
