PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip...
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis
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Author / Creator
Tuo, Lin , Xiang, Jin , Pan, Xuanming , Hu, Jieli , Tang, Hua , Liang, Li , Xia, Jie , Hu, Yuan , Zhang, Wenlu , Huang, Ailong , Wang, Kai and Tang, Ni
Publisher
London: BioMed Central Ltd
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Language
English
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Publisher
London: BioMed Central Ltd
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Background Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated in hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexpression of PCK1 has been shown to suppress liver tumor grow...
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Full title
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis
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TN_cdi_doaj_primary_oai_doaj_org_article_098f549e562440f1980394c9d9c3365b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_098f549e562440f1980394c9d9c3365b
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-019-1029-y
