Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the...
Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes. OSI-906 (linsitinib), an anti-tumor drug, is an orally bioavailable dual inhibitor of IR and IGF1R. To investigate the recovery from metabolic changes induced by the acute inhibition of I...
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Full title
Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906
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TN_cdi_doaj_primary_oai_doaj_org_article_09a9086494a640ca8284695f8b491659
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_09a9086494a640ca8284695f8b491659
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-04304-5
