Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resista...
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
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Author / Creator
Pavlidis, Polychronis , Tsakmaki, Anastasia , Pantazi, Eirini , Li, Katherine , Cozzetto, Domenico , Digby- Bell, Jonathan , Yang, Feifei , Lo, Jonathan W. , Alberts, Elena , Sa, Ana Caroline Costa , Niazi, Umar , Friedman, Joshua , Long, Anna K. , Ding, Yuchun , Carey, Christopher D. , Lamb, Christopher , Saqi, Mansoor , Madgwick, Matthew , Gul, Leila , Treveil, Agatha , Korcsmaros, Tamas , Macdonald, Thomas T. , Lord, Graham M. , Bewick, Gavin and Powell, Nick
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial. Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial organoids and evaluate the biological, functional and clinical significance of the IL-22 mediated pathways in ulcerative colitis (UC). We show that IL-22 regulated...
Alternative Titles
Full title
Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
Authors, Artists and Contributors
Author / Creator
Tsakmaki, Anastasia
Pantazi, Eirini
Li, Katherine
Cozzetto, Domenico
Digby- Bell, Jonathan
Yang, Feifei
Lo, Jonathan W.
Alberts, Elena
Sa, Ana Caroline Costa
Niazi, Umar
Friedman, Joshua
Long, Anna K.
Ding, Yuchun
Carey, Christopher D.
Lamb, Christopher
Saqi, Mansoor
Madgwick, Matthew
Gul, Leila
Treveil, Agatha
Korcsmaros, Tamas
Macdonald, Thomas T.
Lord, Graham M.
Bewick, Gavin
Powell, Nick
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_09b1e8f2868c4b6694a41d33bf89af3b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_09b1e8f2868c4b6694a41d33bf89af3b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33331-8
