Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and infl...
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
About this item
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Author / Creator
Dondelinger, Yves , Delanghe, Tom , Priem, Dario , Wynosky-Dolfi, Meghan A. , Sorobetea, Daniel , Rojas-Rivera, Diego , Giansanti, Piero , Roelandt, Ria , Gropengiesser, Julia , Ruckdeschel, Klaus , Savvides, Savvas N. , Heck, Albert J. R. , Vandenabeele, Peter , Brodsky, Igor E. and Bertrand, Mathieu J. M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 paradoxically induces these cell death modalities. The molecular switch between RIPK1 pro-survival and pro-death functions remains poor...
Alternative Titles
Full title
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_09b6a96e862a47278fdf07e7af978602
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_09b6a96e862a47278fdf07e7af978602
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09690-0
