R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral...
R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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LRRK2 mutations are closely associated with Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations—G2019S and R1441C—we investigated how LRRK2 mutations altered striatal physiology. While we found that both R1441C an...
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R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
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TN_cdi_doaj_primary_oai_doaj_org_article_0a23718f268548469f30d522e7f56b2e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0a23718f268548469f30d522e7f56b2e
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-022-04136-8
