Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding...
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
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Author / Creator
Yuan, Yuan , Cao, Duanfang , Zhang, Yanfang , Ma, Jun , Qi, Jianxun , Wang, Qihui , Lu, Guangwen , Wu, Ying , Yan, Jinghua , Shi, Yi , Zhang, Xinzheng and Gao, George F.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle c...
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Full title
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
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TN_cdi_doaj_primary_oai_doaj_org_article_0a48ce79c98942e39775d23cb6720f81
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0a48ce79c98942e39775d23cb6720f81
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15092
