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CREB3 gain of function variants protect against ALS

CREB3 gain of function variants protect against ALS

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0a55d58b8fd342a4a32ca5f5bc01b909

CREB3 gain of function variants protect against ALS

About this item

Full title

CREB3 gain of function variants protect against ALS

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2025-03, Vol.16 (1), p.2942-17, Article 2942

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly evolving neurodegenerative disease arising from the loss of glutamatergic corticospinal neurons (CSN) and cholinergic motoneurons (MN). Here, we performed comparative cross-species transcriptomics of CSN using published snRNA-seq data from the motor cortex of ALS and control postmortem tiss...

Alternative Titles

Full title

CREB3 gain of function variants protect against ALS

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_0a55d58b8fd342a4a32ca5f5bc01b909

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0a55d58b8fd342a4a32ca5f5bc01b909

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-025-58098-6

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