Mapping protein binding sites by photoreactive fragment pharmacophores
Mapping protein binding sites by photoreactive fragment pharmacophores
About this item
Full title
Author / Creator
Ábrányi-Balogh, Péter , Bajusz, Dávid , Orgován, Zoltán , Keeley, Aaron B. , Petri, László , Péczka, Nikolett , Szalai, Tibor Viktor , Pálfy, Gyula , Gadanecz, Márton , Grant, Emma K. , Imre, Tímea , Takács, Tamás , Ranđelović, Ivan , Baranyi, Marcell , Marton, András , Schlosser, Gitta , Ashraf, Qirat F. , de Araujo, Elvin D. , Karancsi, Tamás , Buday, László , Tóvári, József , Perczel, András , Bush, Jacob T. and Keserű, György M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Fragment screening is a popular strategy of generating viable chemical starting points especially for challenging targets. Although fragments provide a better coverage of chemical space and they have typically higher chance of binding, their weak affinity necessitates highly sensitive biophysical assays. Here, we introduce a screening concept that...
Alternative Titles
Full title
Mapping protein binding sites by photoreactive fragment pharmacophores
Authors, Artists and Contributors
Author / Creator
Bajusz, Dávid
Orgován, Zoltán
Keeley, Aaron B.
Petri, László
Péczka, Nikolett
Szalai, Tibor Viktor
Pálfy, Gyula
Gadanecz, Márton
Grant, Emma K.
Imre, Tímea
Takács, Tamás
Ranđelović, Ivan
Baranyi, Marcell
Marton, András
Schlosser, Gitta
Ashraf, Qirat F.
de Araujo, Elvin D.
Karancsi, Tamás
Buday, László
Tóvári, József
Perczel, András
Bush, Jacob T.
Keserű, György M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0a79f05dcd144d4ba343eaa1f806db99
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0a79f05dcd144d4ba343eaa1f806db99
Other Identifiers
ISSN
2399-3669
E-ISSN
2399-3669
DOI
10.1038/s42004-024-01252-w
