Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia
Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia
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Author / Creator
Bao, Xiuqin , Gao, Yuanyi , Wang, Zhongju , Ye, Yuhua , Chen, Diyu , Zuo, Yangjin , Zhao, Cunyou and Xu, Xiangmin
Publisher
Germany: BioMed Central
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Language
English
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Publisher
Germany: BioMed Central
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Contents
The mechanism that drives the switch from fetal to adult hemoglobin (Hb) provides a therapeutic target for β-thalassemia. We have previously identified that hypermethylation of transcription factor ERF promoter reactivated γ-globin expression. To uncover the mechanism underlying the hypermethylation of ERF promoter, we performed RNA sequencing in β...
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Full title
Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0aa26d52d8a142a59376cc32bd6068e3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0aa26d52d8a142a59376cc32bd6068e3
Other Identifiers
ISSN
1868-7083
E-ISSN
1868-7083,1868-7075
DOI
10.1186/s13148-023-01614-6
