Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and ch...
Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
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Author / Creator
Carraro, Caterina , Bonaguro, Lorenzo , Schulte-Schrepping, Jonas , Horne, Arik , Oestreich, Marie , Warnat-Herresthal, Stefanie , Helbing, Tim , De Franco, Michele , Haendler, Kristian , Mukherjee, Sach , Ulas, Thomas , Gandin, Valentina , Goettlich, Richard , Aschenbrenner, Anna C , Schultze, Joachim L and Gatto, Barbara
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Omics-based technologies are driving major advances in precision medicine, but efforts are still required to consolidate their use in drug discovery. In this work, we exemplify the use of multi-omics to support the development of 3-chloropiperidines, a new class of candidate anticancer agents. Combined analyses of transcriptome and chromatin access...
Alternative Titles
Full title
Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
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TN_cdi_doaj_primary_oai_doaj_org_article_0ad35f19a474450691b8671650825bc3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ad35f19a474450691b8671650825bc3
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.78012
