ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Targetable drivers governing 5-fluorouracil and cisplatin (5FU + CDDP) resistance remain elusive due to the paucity of physiologically and therapeutically relevant models. Here, we establish 5FU + CDDP resistant intestinal subtype GC patient-derived organoid lines. JAK/STAT signaling and its downstream, adenosine deaminases acting on RNA 1 (ADAR1),...
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Full title
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_0ad6ea25978a47d9b5edba84b643c792
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ad6ea25978a47d9b5edba84b643c792
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-38581-8
