A Brownian ratchet model for DNA loop extrusion by the cohesin complex
A Brownian ratchet model for DNA loop extrusion by the cohesin complex
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Publisher
England: eLife Science Publications, Ltd
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English
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Publisher
England: eLife Science Publications, Ltd
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Contents
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. ATP and DNA binding promote cohesin conformational changes that guide DNA through a kleisin N-gate into a...
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Full title
A Brownian ratchet model for DNA loop extrusion by the cohesin complex
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TN_cdi_doaj_primary_oai_doaj_org_article_0ae9e448ae33441086314aaa5c718bc9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ae9e448ae33441086314aaa5c718bc9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.67530
