ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or...
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses globally suppress protein synthesis through the integrated stress response (ISR), resulting in preferential translation of the transcription factor ATF-4. Here we show in
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Full title
ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
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TN_cdi_doaj_primary_oai_doaj_org_article_0b2d369bb38048e0accd70b4ceb4ae16
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0b2d369bb38048e0accd70b4ceb4ae16
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28599-9
