STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the...
STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA is unclear. Previous research demonstrated that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) participates in DNA damage response. As a result, the current study aimed at explor...
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STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-κB signaling pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_0b5773c168094526878483423229b800
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0b5773c168094526878483423229b800
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ISSN
2041-4889
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2041-4889
DOI
10.1038/s41419-020-03341-9
