Breast cancer genome and transcriptome integration implicates specific mutational signatures with im...
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
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Author / Creator
Smid, Marcel , Rodríguez-González, F. Germán , Sieuwerts, Anieta M. , Salgado, Roberto , Prager-Van der Smissen, Wendy J. C. , Vlugt-Daane, Michelle van der , van Galen, Anne , Nik-Zainal, Serena , Staaf, Johan , Brinkman, Arie B. , van de Vijver, Marc J. , Richardson, Andrea L. , Fatima, Aquila , Berentsen, Kim , Butler, Adam , Martin, Sancha , Davies, Helen R. , Debets, Reno , Gelder, Marion E. Meijer-Van , van Deurzen, Carolien H. M. , MacGrogan, Gaëtan , Van den Eynden, Gert G. G. M. , Purdie, Colin , Thompson, Alastair M. , Caldas, Carlos , Span, Paul N. , Simpson, Peter T. , Lakhani, Sunil R. , Van Laere, Steven , Desmedt, Christine , Ringnér, Markus , Tommasi, Stefania , Eyford, Jorunn , Broeks, Annegien , Vincent-Salomon, Anne , Futreal, P. Andrew , Knappskog, Stian , King, Tari , Thomas, Gilles , Viari, Alain , Langerød, Anita , Børresen-Dale, Anne-Lise , Birney, Ewan , Stunnenberg, Hendrik G. , Stratton, Mike , Foekens, John A. and Martens, John W. M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
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Contents
A recent comprehensive whole genome analysis of a large breast cancer cohort was used to link known and novel drivers and substitution signatures to the transcriptome of 266 cases. Here, we validate that subtype-specific aberrations show concordant expression changes for, for example,
TP53, PIK3CA, PTEN, CCND1
and
CDH1
. We find that
Alternative Titles
Full title
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Authors, Artists and Contributors
Author / Creator
Rodríguez-González, F. Germán
Sieuwerts, Anieta M.
Salgado, Roberto
Prager-Van der Smissen, Wendy J. C.
Vlugt-Daane, Michelle van der
van Galen, Anne
Nik-Zainal, Serena
Staaf, Johan
Brinkman, Arie B.
van de Vijver, Marc J.
Richardson, Andrea L.
Fatima, Aquila
Berentsen, Kim
Butler, Adam
Martin, Sancha
Davies, Helen R.
Debets, Reno
Gelder, Marion E. Meijer-Van
van Deurzen, Carolien H. M.
MacGrogan, Gaëtan
Van den Eynden, Gert G. G. M.
Purdie, Colin
Thompson, Alastair M.
Caldas, Carlos
Span, Paul N.
Simpson, Peter T.
Lakhani, Sunil R.
Van Laere, Steven
Desmedt, Christine
Ringnér, Markus
Tommasi, Stefania
Eyford, Jorunn
Broeks, Annegien
Vincent-Salomon, Anne
Futreal, P. Andrew
Knappskog, Stian
King, Tari
Thomas, Gilles
Viari, Alain
Langerød, Anita
Børresen-Dale, Anne-Lise
Birney, Ewan
Stunnenberg, Hendrik G.
Stratton, Mike
Foekens, John A.
Martens, John W. M.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0b80834b0f74411a8fac98a9ae2db59b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0b80834b0f74411a8fac98a9ae2db59b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12910
