Prime editing for functional repair in patient-derived disease models
Prime editing for functional repair in patient-derived disease models
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Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Prime editing is a recent genome editing technology using fusion proteins of Cas9-nickase and reverse transcriptase, that holds promise to correct the vast majority of genetic defects. Here, we develop prime editing for primary adult stem cells grown in organoid culture models. First, we generate precise in-frame deletions in the gene encoding β‐ca...
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Prime editing for functional repair in patient-derived disease models
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TN_cdi_doaj_primary_oai_doaj_org_article_0ba02ae845834a578eb870a005592a64
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ba02ae845834a578eb870a005592a64
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19136-7
