Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal...
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
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Author / Creator
Sun, Mingming , Wu, Wei , Chen, Liang , Yang, Wenjing , Huang, Xiangsheng , Ma, Caiyun , Chen, Feidi , Xiao, Yi , Zhao, Ye , Ma, Chunyan , Yao, Suxia , Carpio, Victor H. , Dann, Sara M. , Zhao, Qihong , Liu, Zhanju and Cong, Yingzi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short-chain fatty acids (SCFAs) promote microbiota antigen-specific Th1 cell IL-10 production, mediated by G-protein coupled receptors 43 (GPR43). Microbiota antigen-spe...
Alternative Titles
Full title
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0ba5e8cba7f0472bb973f7f9800301ee
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0ba5e8cba7f0472bb973f7f9800301ee
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05901-2
