Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination cond...
Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions
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England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP. Guanine nucleotide homeostasis is central to photoreceptor cells, where cGMP is the signal transducing molecul...
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Full title
Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions
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TN_cdi_doaj_primary_oai_doaj_org_article_0bb5adc61dcb4789b7eeb46936f8f9d9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0bb5adc61dcb4789b7eeb46936f8f9d9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.56418
